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The following mutations did not affect GLP-1 pharmacology: F266 4.42b A, R267 4.43b A, L268 4.44b A, L278 4.54b M, G285 4.61b A, I286 4.62b A/V287 4.63b A, I286 4.62b A, V287 4.63b A, Y289 4.65b A, L290 4.66b A/Y291 4.67b A, L290 4.66b A, and Y291 4.67b A (Mathi et al., 1997
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