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The effects of overexpressing FXR were recovered by limiting miR-33 expression, demonstrating that FXR decreased GLP-1 secretion via boosting miR-33 expression and, by extension, GCG and CREB1 expression

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The Preclinical Foundation Before human clinical trials began, the case for GLP-1 agonists in addiction was built on a robust body of animal research spanning more than a decade