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They reviewed data from the largest and longest GLP-1 trial for obesity treatment, with over 17,000 participants, and found that decreased waist circumference was only responsible for about one-third of the 20% decrease in MACE
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The most common side effects reported in SURPASS 1 trial (as compared with placebo) were abdominal discomfort, nausea, diarrhoea (12–18%), injection site reactions (2–3%), and hypersensitivity (1–2%)
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