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How GLP-1 weight loss medications work and their limitations
GLP-1 receptor agonists are FDA-approved therapies for T2DM, and recent studies have explored their potential as repurposed treatments for neurodegenerative diseases, including PD, AD, and ALS, as well as cerebrovascular disorders
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Given the rapid degradation of intestinally secreted GLP-1 by DPP-4, there are suggestions that these GLP-1 receptors are activated locally—i.e., by gastric-produced GLP-1
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