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Prominent in neurons, but not glial cells, GIP synthesis is more distributed in the CNS compared to GLP-1 and was identified in the hippocampal CA1-3, granule cell layer and neurogenic niche of the dentate gyrus, thalamus, cerebral cortex, cerebellum (Purkinje cells) and brainstem
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3 In a pre-specified analysis of time to first MACE-5, a composite of all-cause death, heart attack, stroke, heart failure event or coronary revascularization, there were 44 events in the Retatrutide group versus 52 in the placebo group, yielding a hazard ratio of 0.82 (95% CI: 0.55 to 1.22)
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