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Randomization was stratified according to country, sex (female, male) and per cent weight reduction at the end of lead-in ( 90% to demonstrate the superiority of tirzepatide MTD to placebo, for the coprimary endpoints, each at a two-sided significance level of 0.05
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Some studies suggest that meals containing adequate protein may increase postprandial GLP-1 levels compared to lower-protein meals, though specific gram targets vary by individual needs
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