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GLP-1 agonists lower blood pressure by affecting the Na/H channel in the proximal tubule and protect against cardiac hypertrophy [94,112]

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From the pharmacological point of view, signaling studies have shown that tirzepatide has mimetic effects of native GIP at the GIP receptor but shows bias at the GLP-1 receptor to promote cAMP generation over β-arrestin recruitment, which is in line with a weaker ability to induce GLP-1 receptor internalization compared to GLP-1 (38)