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Similarly, the dual GLP-1R and GIP agonist tirzepatide promoted the intake of standard rodent chow at the expense of a high-fat diet in mice, suggesting a preferential shift toward less energy-dense foods (Geisler et al., 2023)
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The consensus among diabetes specialists is that semaglutide is not contraindicated in Type 1 diabetes but should only be considered for patients with body mass index (BMI) above 27 kg/m² who have failed other weight loss methods and who have access to an endocrinologist experienced in insulin adjustment
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