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Possible side effects of orlistat (Xenical/Alli) While the active ingredient orlistat — which works by inhibiting the enzymes that break down fat in the gut, preventing your body from absorbing it — debuted back in 1999 to a lot of fanfare, Fishman says it’s become less popular for two big reasons: “side effects and minimal benefits.” Those side effects are mostly gastrointestinal, and can include abdominal pain in up to 30% of patients
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2022;48(5) doi: 10.1016/j.diabet.2022.101366
