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Practical Guidance If you choose to drink on a GLP-1 medication: Keep intake to 1 standard drink (5 oz wine, 12 oz beer, 1.5 oz spirits) maximum on any given day Never drink on an empty stomach — pair alcohol with a protein-containing meal Drink water before, during, and after — 1:1 ratio Never combine alcohol with insulin or sulfonylurea medications without extra caution Avoid sweetened cocktails (double impact: alcohol + sugar) Do not drink on the day of a dose increase — side effects are worst that week The safest recommendation is to eliminate alcohol entirely during active weight loss on a GLP-1

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This has been reported more frequently with the use of agents with prolonged half-lives