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however, the impact of this combination therapy on blood pressure (BP) has not been fully evaluated
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In the vasculature, GLP-1RAs and DPP-4 inhibitors mitigate LPS-induced endothelial permeability, inflammation, and microvascular thrombosis by activating AMPK and CaMKKβ, reducing adhesion molecule expression (VCAM-1, ICAM-1), and improving outcomes in septic shock
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