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The cardiovascular outcomes trials that enrolled tens of thousands of patients with type 2 diabetes—including LEADER (liraglutide), SUSTAIN-6 (semaglutide), REWIND (dulaglutide), and EXSCEL (exenatide ER)—found no significant increase in overall cancer incidence compared to placebo over follow-up periods ranging from approximately two to five years

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Orforglipron demonstrated clear superiority, with an HbA1c reduction of -2.2% vs