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Of particular interest are GLP-1/GCG dual-receptor agonists, especially those targeting GLP-1, GIP, and GCG receptors simultaneously.214,215 The activation of GCG receptors is hypothesized to enhance energy expenditure, thereby facilitating weight reduction.216 It is well established that GCG exerts hyperglycemic effects by stimulating hepatic gluconeogenesis, which may be detrimental in diabetic patients

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Liu T, Zhang L, Joo D, Sun SC