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By alleviating chronic systemic inflammation, GLP-1RAs may help prevent the progression of HF and adverse cardiovascular events.14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below
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