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The SUSTAIN trials and multiple randomized controlled studies show measurable weight loss within 12 weeks of semaglutide therapy
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In the OASIS 4 trial, those on oral semaglutide 25mg lost an average of 16.6% of their body weight over 64 weeks.⁴ The trajectory in GLP-1 trials consistently shows that weight loss gradually accelerated as dose titration progresses, with the steepest reductions occurring in the middle months of treatment.⁴ It’s like going to the gym and expecting your ‘gains’ to show by week two, when in reality it can take weeks - or months - of training
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