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EBioMedicine (2021) 65:103242

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As reported by the American Journal of Managed Care, the approval of an oral semaglutide formulation marked the beginning of what many are calling the “oral GLP-1 era.” In December 2025, the FDA approved the Wegovy® (semaglutide) tablet as the first once-daily oral GLP-1 receptor agonist indicated for chronic weight management in adults with obesity or overweight