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It can increase the thermogenesis and utilization of triacylglycerol-derived fatty acids and glucose in brown adipocytes and reduce the lipid content through the central GLP-1R agonists’ signaling pathway, such as central AMP-activated protein kinase or sirtuin-1 (SIRT1), also known as NAD-dependent deacetylase SIRT1 (36–39)
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preferred with heart failure or CKD per ADA 2026 Sulfonylureas (glipizide, glimepiride, glyburide): Stimulate insulin secretion
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