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In obesity and T2D, leptin resistance and higher circulating levels drastically reduce leptin signaling in POMC neurons

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A nationwide Danish-Norwegian cohort study of over 60,000 individuals with type 2 diabetes reported a nearly three-fold increased risk of non-arteritic anterior ischemic optic neuropathy with semaglutide use compared to SGLT-2 inhibitors (HR: 2.81, 95% CI 1.67, 4.75), corresponding to an absolute risk difference of 1.41 events per 10,000 person-years