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Evidence-Based Strategies to Prevent and Relieve Constipation Clinical trials and patient data support several practical interventions: increase water intake to at least 3 liters daily, add high-fiber foods gradually (too much fiber too quickly can worsen bloating), and engage in light physical activity like walking for 20–30 minutes after meals

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MAO Inhibitors: Do not take sertraline if you are also taking monoamine oxidase inhibitors (MAOIs), or if you have taken MAOIs in the last 14 days