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The economic value proposition of Metformin versus newer agents requires consideration of multiple factors: Direct Drug Costs : Generic Metformin versus branded newer agents Complication Prevention : Long-term cardiovascular and renal benefits Healthcare Utilization : Hospitalization rates and emergency interventions Quality of Life : Patient-reported outcomes and functional status 5.2 Global Access and Healthcare Equity From a global health perspective, Metformin’s affordability and widespread availability make it an irreplaceable component of diabetes care in low- and middle-income countries
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