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GLP-1 receptor agonists have transformed the management of metabolic disease including obesity and type 2 diabetes, but as their use increases, we're also learning more about how significant weight loss may affect
The Asp9 forms a hydrogen bond with Arg370, while Ser8 and Ser11 of Tirzepatide form a network of hydrogen bonds involving the receptor residue Glu288, Arg 289, and Asn290
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( 10.1038/s42003-024-06649-w) [DOI] [PMC free article] [PubMed] [Google Scholar] 216