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This deduced primary sequence resembled that of the receptors for secretin, parathyroid hormone, and calcitonin, and hence enabled it to be classified within what was then a new branch of the GPCR superfamily (family B, class B, or secretin receptor-like) that now includes 15 members (Segre and Goldring, 1993

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Se recomienda evaluar la función renal antes de iniciar el tratamiento y periódicamente durante el mismo en pacientes con enfermedad renal preexistente o factores de riesgo