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Weight Loss: In phase III trials, weight loss with the use of exenatide averaged between 0.9 and 2.8 kg over a 30-month time frame, with more weight loss associated when exenatide is added to existing metformin therapy

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The three targets are: Glucose-dependent insulinotropic polypeptide receptor (GIPR) Glucagon-like peptide-1 receptor (GLP-1R) Glucagon receptor (GCGR) Is retatrutide a GLP-1 agonist

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