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- Acute BLM → Gold-standard model for IPF proof-of-concept (#PoC) and comparison with approved therapies - Chronic BLM → Persistent fibrosis for long-term efficacy evaluation - Silica → Sustained fibrotic pathology resembling chronic progressive fibrosis - SSc-ILD → Simultaneous evaluation of skin and lung fibrosis in systemic sclerosis The Acute Bleomycin model is particularly valuable for early-stage screening, benchmarking against approved anti-fibrotic drugs, and evaluating novel therapies targeting idiopathic pulmonary fibrosis (IPF)