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Across the SUSTAIN program, once-weekly subcutaneous semaglutide 1.0 mg reduced HbA 1c by 1.5–1.8% after 30–56 weeks, which was significantly more than sitagliptin, liraglutide, exenatide extended release, dulaglutide, canagliflozin, or insulin glargine
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37 , 40 Concomitantly, circulating pro‐inflammatory cytokines such as tumour necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and interleukin‐1β (IL‐1β) can cross the blood–brain barrier (BBB) or alter its integrity, thereby promoting microglial activation and astrocytic reactivity
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