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The Bottom Line: How MariTide Works MariTide works by combining two powerful actions: Activating the GLP-1 receptor Blocking the GIP receptor (GIPR antagonism) This dual approach may offer: Significant weight loss Improved blood sugar control Better cardiometabolic health Convenient monthly injection Although more data is needed from ongoing and future Phase 3 trials, early results suggest MariTide could become a major new option in the obesity drug landscape once evaluated by the Food and Drug Administration and other global regulators