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Efficacy of DPP-4 inhibitors and GLP-1RAs in clinical trials In clinical trials, comparable HbA1c reductions of 0.4–0.7% have been reported with sitagliptin (100 mg OD), vildagliptin (50 mg BID), saxagliptin (5 mg OD), or liniagliptin (5 mg OD) monotherapy for 26 weeks 23
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The approval gives Ozempic (semaglutide) the broadest label in the class, coming after earlier approvals for type 2 diabetes itself and cardiovascular risk reduction in diabetics with known heart disease
