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Some private employers in Maine have also started requiring employees to enroll in wellness programs in order to get insurance coverage of GLP-1s, according to Trevor Putnoky, president of the Healthcare Purchaser Alliance of Maine, a nonprofit research organization

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Nonetheless, although many experimental and clinical findings indicate that DPP-4 plays a role in the pathogenesis of autoimmune diseases, DPP-4 inhibition has controversial effects in autoimmune or inflammatory diseases, which might be related to the ubiquitous tissue distribution and tissue-specific regulation of DPP-4/CD26, as well as to the numerous functions and effects of DPP-4/CD26 [46]