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The most common adverse effects of tirzepatide are gastrointestinal, including nausea (occurring in 20-30% of patients), diarrhea, vomiting, constipation, and abdominal discomfort
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The SURMOUNT trials documented fatigue in 5% at 5 mg, 6% at 10 mg, and 7% at the 15 mg dose versus 3% on placebo
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