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In comparative studies, complete suppression of β-arrestin recruitment produced slower internalization, reduced downregulation, and longer-lasting cAMP signaling than semaglutide [52], indicating that semaglutide retains functionally meaningful arrestin engagement, even if not at the highest level among GLP-1R agonists
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Several variables influence both the pharmacological activity of retatrutide in the body and the physical stability of the compound
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