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For metabolically healthy individuals seeking behavioral nudges, not pharmacological crutches , microdosing represents a compelling middle ground—one that supports long-term adherence to core lifestyle strategies

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However, downregulating PGC-1α eliminated the neuroprotective effects of liraglutide, suggesting that PGC-1α plays a key role in regulating mitochondrial biogenesis, function, autophagy, and apoptosis [74]

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