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Thus, SUs that bind SUR1 to modulate K + ATP channels independently of glucose may also allow GLP-1R agonists to bypass their inherent glucose requirement by stimulating the downstream effects ordinarily associated with increased glucose
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Timing patterns from pooled data The STEP trials pooled data reveals several important timing patterns: The incidence of new-onset nausea was highest during the dose escalation period (weeks 1 to 20) and decreased substantially once participants reached maintenance dosing
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