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The specificity and efficiency of TRβ knockout was confirmed, as evident from the significantly decreased mRNA levels of Thrb in the liver but not in the adipose tissues, muscle, heart, and ileum of LTRβKO mice (Supplementary Fig
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Exendin-4, a GLP-1 receptor agonist similar to the GLP-1 component of tirzepatide, suppressed water intake in rats for more than 4 hours after administration
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