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This work was supported by the China Postdoctoral Science Foundation (Grant #2022YFC3602300 and Grant #2024T171044), the Shenyang Public Health R&D Special Projects in 2022 (Project Grant #22-321-33-10), and the Scientific Research Fund Project of the Department of Education of Liaoning Province (Grant #JCZR2020005)

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Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53