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The short circulating half-life ( t 1/2 ) of native GLP-1 (∼1 minute) makes it unfit as a therapeutic agent, and longer-acting GLP-1RAs with half-lives ranging from ∼2.5 hours to more than a week have been developed for the treatment of both type 2 diabetes and obesity (Table 1) (18)
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Sources: Cleveland Clinic on probiotics, the 2019 human Akkermansia trial, and a 2026 human Akkermansia trial
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