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Mechanistically, appetite suppression and delayed gastric emptying can undermine caloric intake and glycogen repletion, posing risks for endurance, power output, and recovery in elite athletes

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The mechanism is specific and brutal: hypothalamic damage reduces production of alpha-melanocyte-stimulating hormone (ฮฑ-MSH), a neuropeptide that under normal conditions activates the melanocortin-4 receptor (MC4R)

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