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The STEP trials, which evaluated semaglutide, followed patients for up to three years in extension studies, showing that weight loss plateaus rather than reverses when treatment continues as prescribed

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Experimental studies have explored GLP-1 activity in models studying: • glucose metabolism research • insulin signaling pathways • incretin receptor activity • GLP-1 receptor characterization • metabolic hormone signaling Published literature commonly references GLP-1 receptor activity in the context of glucose-homeostasis research models