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DOI: Supplementary Material: video-s1, video-s2, video-s3 Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are frequently used for diabetes and weight loss management

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Other findings included: Gallbladder issues (especially with rapid weight loss) Pancreatitis (rare, with unclear causality) Thyroid C-cell hyperplasia (in animals, not seen in humans) Lean mass loss—up to 40% of weight lost may be muscle in older adults None of these derailed regulatory approvals