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Moreover, GLP-1RA exendin-4 improves insulin resistance by directly inhibiting the activation of nuclear factor-kappa-B (NF-κB) within the murine macrophage cell line RAW264.7 [88, 89]
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The short-acting agents have less impact on A1C and weight and high rates of GI AEs, and thus should not routinely be considered first-line agents
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