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Despite being similar to natural GLP-1, liraglutide has a unique property - it is resistant to degradation by dipeptidyl peptidase 4 (DPP-4) and neutral endopeptidases (NEP)
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Ligand activation of this latter isoform does not lead to the generation of cyclic AMP, thereby attenuating the ability of the wild-type receptor to activate this pathway (60)
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