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doi: 10.3389/fmicb.2025.1651965 Received 22 June 2025 Accepted 25 September 2025 Published 17 October 2025 Volume 16 - 2025 Edited by João Miguel Rocha, Laboratory of Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Portugal Reviewed by Kimon Andreas Karatzas, University of Reading, United Kingdom Abdul Bari Shah, Al-Farabi Kazakh National University, Kazakhstan Updates Copyright © 2025 Kezer, Paramithiotis, Khwaldia, Harahap, Čagalj, Šimat, Smaoui, Elfalleh, Ozogul and Esatbeyoglu

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However, the indirect comparisons of semaglutide 1.0 mg versus dulaglutide 3.0 and 4.5 mg were anchored to dulaglutide 1.5 mg, making it possible to conduct a robust analysis without further adjustment for differences in prognostic factors across trials