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It has been proven that glucagon-like peptide-1 receptor (GLP-1R) agonists control blood glucose concentrations through a multitude of mechanisms, such as increased satiety, slow stomach emptying, decreased glucagon secretion, and increased insulin synthesis/secretion

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Pooled analyses from trials such as SUSTAIN-6 and LEADER reported reductions in albuminuria and slower declines in estimated glomerular filtration rates (eGFR), with pronounced benefits observed in those with lower baseline eGFR (41)