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F.4 Limitations of This Report This report synthesizes existing evidence and does not present original clinical data The rapidly evolving evidence base means that some information may be superseded by new publications after the search cutoff date (February 2025) Real-world evidence (RWE) studies cited in this report are subject to the inherent limitations of observational study designs (confounding, selection bias, information bias) Compounding pharmacy information reflects the regulatory landscape as of early 2025 and may change as FDA policy evolves Cost information reflects US pricing and may not be applicable to other healthcare systems Emerging indications discussed in this report are based on preliminary evidence and should not be used to guide clinical decision-making without consultation with a qualified healthcare provider This report will be updated periodically as new evidence becomes available