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Medication:Tirzepatide (GLP-1 + GIP)
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 19–26% of participants (vs 9% on placebo) Nausea: 13–18% (vs 2% on placebo) Constipation: 8–17% (vs 4% on placebo) Vomiting: 5–14% (vs 1% on placebo) Across multiple studies, 6–17% of people stopped treatment because of side effects, mostly gut-related symptoms
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