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SMG weight-lowering effects are mediated through central and peripheral mechanisms that regulate appetite, energy balance, and metabolism (Figure 1)

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"Today's decision by the FDA reflects the continued progress in how we understand and treat patients with MASH, bringing us closer to care that meets the needs of people living with this disease." - Arun Sanyal, MD, director, Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, Virginia Commonwealth University Nearly 1 in 20 US individuals are living with MASH—a severe form of fatty liver disease that can cause life-threatening outcomes if not treated properly—and around 1 in 3 individuals who are living with overweight or obesity also have MASH