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Generation 1 (2005-2014): Daily and twice-daily injectables Exenatide (Byetta): twice-daily injection, approved 2005 Liraglutide (Victoza): once-daily injection, approved 2010 Exenatide extended-release (Bydureon): once-weekly injection, approved 2012 These medications established proof-of-concept for GLP-1 therapy but required daily dosing (except Bydureon) and produced modest weight loss (5-8% total body weight)

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First-line recommendations from the American Diabetes Association, American College of Physicians, and U.S