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While these agents show great therapeutic efficacy in improving body weight and glycemic control, their use in developing organisms raises concerns about pleiotropic effects and impairment in developmental plasticity, requiring integrative approaches and cautious evaluation
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Novartis Pluvicto established radioligand therapy as a commercial reality (2022+): Lutetium-177 PSMA-617 (Pluvicto) for metastatic castration-resistant prostate cancer achieved rapid adoption post-2022 launch, validating the peptide receptor radionuclide therapy platform and creating a template for multiple follow-on radioligand therapy programmes
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