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Our finding of increased incidence of PDR in tirzepatide-exposed individuals contrasts with the low rates of PDR reported in the SURPASS 1–5 clinical trials, which reported a total of 21 adverse retinal events in tirzepatide-exposed individuals and 19 events in tirzepatide-unexposed individuals [13]

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DOI: Published online: May 22, 2025 1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea 2 Department of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea 3 Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea Corresponding author: Young Min Cho Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea E-mail: [email protected] *Serin Hong, Byung Soo Kong, and Hyunsuk Lee contributed equally to this study as first authors