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There are some studies using lactisole, a sweet taste receptor antagonist, that have shown reduced GLP-1 and PYY secretion in response to glucose, but no effect on CCK release (68–70)
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A 2021 New England Journal of Medicine study found that combining semaglutide with lifestyle interventions, including exercise, led to an average 14.9% weight loss over 68 weeks—significantly more than lifestyle changes alone
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