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Such mechanisms occur very rapidly, within 5–15 min upon receptor binding, indicating that the actions are not mediated by altered gene expression, but likely by phosphorylation of protein components of the secretory machinery 13

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↑ "A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes (SUSTAIN)"